|About the Book|
Previous studies have shown that the Human Leukocyte Antigen (HLA) class I and II might be associated with alopecia areata. In particular, HLA class II alleles DR4, DR5, DR6, and DQ3 have been most frequently associated with alopecia areata.MorePrevious studies have shown that the Human Leukocyte Antigen (HLA) class I and II might be associated with alopecia areata. In particular, HLA class II alleles DR4, DR5, DR6, and DQ3 have been most frequently associated with alopecia areata. DRB1*0401 and DQB1*030 alleles have a higher frequency in the more severe forms of alopecia . However, there have not been any studies of the frequency of non-classical HLA class I HLA-E alleles. The goal of this study was to determine if there were any associations in HLA-E polymorphism of alopecia areata patients in Caucasian and Jewish populations. We have investigated the allele frequency of HLA-E in 72 alopecia areata patients, 42 related controls, and 55 random controls by amplification refractory mutation system (ARMS) analysis. Expression of HLA-E*0101/01031 was decreased in alopecia areata patients compared to control group (P=0.000302). Frequency of E*0101/01032 in alopecia patients was increased compared to the control group (P=0.0162). Also, the frequency of E*01031/01032 increased in alopecia patients versus controls (P=0.0419). E*0101/01031 frequency showed a strong negative association with the risk of AAP (P=0.0122). E*0101/01031 NS 0101/1032 were strongly associated with risk of alopecia totalis (P=0.0087, and 0.0098 respectively). Furthermore, E*0101/01031, 0101/01032, and 01032/01032 were strongly associated with risk of alopecia universalis (P=0.0087, 0.0098, and 0.0274 respectively).